12th International Meeting "Steroids and Nervous System” Torino (Italy) February 24-27, 2024
https://www.neurosteroids.unito.it/home-page
Organizing Committee
Roberto C. Melcangi
Silvia Giatti
Stefano Gotti
Internation Scientific Committee
Charlotte Cornil
George Barreto
Karin M. Frick
Liisa Galea
Onno Meijer
Dear Colleague,
the registration and abstract submission for the next meeting (February 24-27, 2024) is now open:
https://www.neurosteroids.unito.it/registration
https://www.neurosteroids.unito.it/abstract-submission
you may have a look on the program at:
https://www.neurosteroids.unito.it/scientific-program
As for previous meetings we are engaged in facilitating the attendance of young people, therefore we have a program of small support for young researchers attending to the meeting and presenting an abstract.
The request for these fellowships in now open:
https://www.neurosteroids.unito.it/fellowship-request
Deadlines:
https://www.neurosteroids.unito.it/deadlines
Looking forward to your attendance
Roberto Cosimo Melcangi, Silvia Giatti and Stefano Gotti
Our lab warmly welcomes Dr. Lanussa, as a Postdoctoral fellow! We extend our best wishes for success in your research endeavours and hope that your time in our laboratory will yield both academic and personal accomplishments. This marks the beginning of an exhilarating venture, and we are thrilled to have you as a member of our team! Welcome again and enjoy UL and Limerick!
We review the current literature on tibolone and its effects on cognitive function. Some studies have shown that tibolone can improve cognitive function in postmenopausal women, while others have found no significant effect.
Our new review is out!!! In this paper we highlight the potential of tibolone, a synthetic steroid hormone, as a treatment for Alzheimer's disease. We begin by discussing the role of hormones, particularly estrogen, in the development of Alzheimer's disease. We explain that hormone loss, particularly in post-menopausal women, is associated with an increased risk of developing Alzheimer's disease. We then introduce tibolone, a pro-synthetic drug approved by the FDA for the reduction of adverse menopausal symptoms in women. Tibolone has been shown to have broad anti-inflammatory and antioxidant effects by activating estrogen receptor alpha (ERα) and ERβ, progesterone (PGR) and androgen (AR) receptors.
We then look at tibolone's potential as a treatment for Alzheimer's disease. Tibolone may be able to alleviate some of the negative effects of hormone loss, such as inflammation and oxidative stress, which are hallmarks of Alzheimer's disease. Several studies have investigated the effects of tibolone on Alzheimer's disease, including animal studies and clinical trials. While the results of these studies are mixed, we conclude that tibolone shows promise as a treatment for Alzheimer's disease, but more research is needed to fully understand its potential benefits and drawbacks.
Our new paper is out!!! In collaboration with David Ramírez (University of Concepción, Chile) and Janneth Gonzalez (Pontificia Universidad Javeriana, Colombia), we explored the potential of tibolone, a synthetic steroid hormone, as a treatment for traumatic brain injury (TBI). We used network pharmacology and topological analysis to identify the molecular mechanisms of tibolone metabolites in TBI. We found that tibolone and its metabolites regulate multiple pathways involved in inflammation, oxidative stress, and neuronal death. Finally, we also identified several molecular targets, including KDR, ESR2, AR, NR3C1, PPARD, and PPARA , which are known to play critical roles in the pathogenesis of TBI.This involved the genes.
Interested in TBI research? Check it out: https://doi.org/10.1016/j.biopha.2023.115089
12th International Meeting "Steroids and Nervous System” Torino (Italy) February 24-27, 2024
https://www.neurosteroids.unito.it/home-page
Organizing Committee
Roberto C. Melcangi
Silvia Giatti
Stefano Gotti
Internation Scientific Committee
Charlotte Cornil
George Barreto
Karin M. Frick
Liisa Galea
Onno Meyer
The program of our next meeting (February 24-27, 2024) is now available:
https://www.neurosteroids.unito.it/scientific-program
Early registration and abstract submission will open on September 18, and close on December 18, 2023.
As for previous meetings we are engaged in facilitating the attendance of young people, therefore we have a program of small support for young researchers attending to the meeting and presenting an abstract.
The request for these fellowships will open on September 18 and close on November 16, 2023.
Looking forward to your attendance!
The Organizing Committee
A new collaborative work with Dag Aarsland & Team (Norway) is now out! In this study, Alberto Jaramillo-Jimenez suggests that abnormalities in the TCA cycle could be linked to cognitive decline in mild dementia patients. Serum TCA cycle metabolites were analyzed in a cohort of mild dementia patients, and potential interactions with Lewy Body Dementia (LBD) or Alzheimer's Disease (AD) and APOE-ε4 genotype were explored. The study found that serum citrate concentrations could be associated with subsequent cognitive decline, as well as isocitrate concentrations in APOE-ε4 carriers. The findings could be significant in the development of early interventions for cognitive decline in mild dementia patients.
Check it out: https://www.sciencedirect.com/science/article/pii/S1567724923000399?via%3Dihub
Want to apply to any IBRO grant but do not know how? Check out this Webinar and apply (it's free!):
Link: https://ibro.org/webinar-crafting-ibro-grant-application/
We're excited to welcome Nicole Hofman and Christopher O'Mahoney to our lab! We can't wait to see the fresh ideas and perspectives that they will bring to our ongoing research. Together, we will continue to push the boundaries of science and make new discoveries that will benefit us all. Welcome aboard!
We are sure all Neuroendocrine researchers working on the field met Giancarlo Panzica, one of the organizers of the International Meeting on Steroids and Nervous System, at some stage in their academic career. Unfortunately, he passed away in July of this year. To celebrate our colleague and friend, a symposium " State of the art on Steroids and Nervous System: In memory of Giancarlo" will be organized virtually on February 23-24, 2023.
https://www.neurosteroids.unito.it/scientific-program
Attendance will be free, but due to the limited number of access to the event, an email registration will be needed (please reply to neurosteroids@unito.it).
Want to know more about phloretin, a natural estrogen receptor agonist? Take a look at our new published paper on its antioxidant and anti-inflammatory effects. This study was developed by Kubra Ongay, as part of her MSc Biomolecular Science thesis, and in collaboration with Daniel Granato. More exciting results coming up!!!!
