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Most conversations about #menopause focus on hot flashes, sleep disruption, hormonal shifts. But there's a less-told story happening in the brain.
Estrogen isn’t just a reproductive hormone. It actively shapes brain function, supporting memory, regulating mood, and helping maintain cellular health. When levels decline, that support system shifts.
For many women, this results in brain fog, difficulty concentrating, or subtle changes in memory. Over time, these changes may be linked to a higher risk of neurodegenerative diseases like Alzheimer’s, where women account for nearly two-thirds of cases.
The reasons are complex and still being unravelled, involving metabolism, inflammation, and how brain cells respond to stress. Understanding these mechanisms is a key focus of our work in our lab.
Do #astrocytes respond to metabolic stress in a sex-specific way?
In this study, human male and female astrocytes were exposed to palmitic acid to investigate how endogenous #estrogen influences cellular responses to lipotoxic stress.
Full Paper Here
Neuroscience #PaperSpotlight #BrainResearch
Do male and female brains respond differently to hormone therapy?
In this study, we show that the brain’s molecular state is shaped by #sex and hormonal environment and this strongly influences the response to treatments like #Tibolone.
These findings highlight the importance of timing and biological context in designing more effective, personalised approaches to brain health.
Please see full paper here
Neuroscience #PaperSpotlight #BrainResearch #HormoneTherapy
By combining experimental screening with computational modeling, we aim to accelerate the discovery of targeted therapies for #neurodegenerative diseases.
#Neuroscience #BrainResearch #ResearchHighlights
Traumatic Brain Injury (#TBI) goes beyond mechanical damage: it disrupts hormones, lipid metabolism, and triggers chronic neuroinflammation.
Discover how our lab models TBI to uncover new therapeutic targets.
Read more in full papers:
In this highlight #2 we uncover how we're decoding hormone-mitochondria interactions.
Read more in our full papers:
