We review the current literature on tibolone and its effects on cognitive function. Some studies have shown that tibolone can improve cognitive function in postmenopausal women, while others have found no significant effect.
Our new review is out!!! In this paper we highlight the potential of tibolone, a synthetic steroid hormone, as a treatment for Alzheimer's disease. We begin by discussing the role of hormones, particularly estrogen, in the development of Alzheimer's disease. We explain that hormone loss, particularly in post-menopausal women, is associated with an increased risk of developing Alzheimer's disease. We then introduce tibolone, a pro-synthetic drug approved by the FDA for the reduction of adverse menopausal symptoms in women. Tibolone has been shown to have broad anti-inflammatory and antioxidant effects by activating estrogen receptor alpha (ERα) and ERβ, progesterone (PGR) and androgen (AR) receptors.
We then look at tibolone's potential as a treatment for Alzheimer's disease. Tibolone may be able to alleviate some of the negative effects of hormone loss, such as inflammation and oxidative stress, which are hallmarks of Alzheimer's disease. Several studies have investigated the effects of tibolone on Alzheimer's disease, including animal studies and clinical trials. While the results of these studies are mixed, we conclude that tibolone shows promise as a treatment for Alzheimer's disease, but more research is needed to fully understand its potential benefits and drawbacks.
Our new paper is out!!! In collaboration with David Ramírez (University of Concepción, Chile) and Janneth Gonzalez (Pontificia Universidad Javeriana, Colombia), we explored the potential of tibolone, a synthetic steroid hormone, as a treatment for traumatic brain injury (TBI). We used network pharmacology and topological analysis to identify the molecular mechanisms of tibolone metabolites in TBI. We found that tibolone and its metabolites regulate multiple pathways involved in inflammation, oxidative stress, and neuronal death. Finally, we also identified several molecular targets, including KDR, ESR2, AR, NR3C1, PPARD, and PPARA , which are known to play critical roles in the pathogenesis of TBI.This involved the genes.
Interested in TBI research? Check it out: https://doi.org/10.1016/j.biopha.2023.115089
12th International Meeting "Steroids and Nervous System” Torino (Italy) February 24-27, 2024
Roberto C. Melcangi
Internation Scientific Committee
Karin M. Frick
The program of our next meeting (February 24-27, 2024) is now available:
Early registration and abstract submission will open on September 18, and close on December 18, 2023.
As for previous meetings we are engaged in facilitating the attendance of young people, therefore we have a program of small support for young researchers attending to the meeting and presenting an abstract.
The request for these fellowships will open on September 18 and close on November 16, 2023.
Looking forward to your attendance!
The Organizing Committee
A new collaborative work with Dag Aarsland & Team (Norway) is now out! In this study, Alberto Jaramillo-Jimenez suggests that abnormalities in the TCA cycle could be linked to cognitive decline in mild dementia patients. Serum TCA cycle metabolites were analyzed in a cohort of mild dementia patients, and potential interactions with Lewy Body Dementia (LBD) or Alzheimer's Disease (AD) and APOE-ε4 genotype were explored. The study found that serum citrate concentrations could be associated with subsequent cognitive decline, as well as isocitrate concentrations in APOE-ε4 carriers. The findings could be significant in the development of early interventions for cognitive decline in mild dementia patients.
We're excited to welcome Nicole Hofman and Christopher O'Mahoney to our lab! We can't wait to see the fresh ideas and perspectives that they will bring to our ongoing research. Together, we will continue to push the boundaries of science and make new discoveries that will benefit us all. Welcome aboard!
We are sure all Neuroendocrine researchers working on the field met Giancarlo Panzica, one of the organizers of the International Meeting on Steroids and Nervous System, at some stage in their academic career. Unfortunately, he passed away in July of this year. To celebrate our colleague and friend, a symposium " State of the art on Steroids and Nervous System: In memory of Giancarlo" will be organized virtually on February 23-24, 2023.
Attendance will be free, but due to the limited number of access to the event, an email registration will be needed (please reply to email@example.com).
Want to know more about phloretin, a natural estrogen receptor agonist? Take a look at our new published paper on its antioxidant and anti-inflammatory effects. This study was developed by Kubra Ongay, as part of her MSc Biomolecular Science thesis, and in collaboration with Daniel Granato. More exciting results coming up!!!!
Our new paper is out!!!
Our finding shows that sex, gonadal hormones, and the hormone replacement therapy Tibolone appears to interact in mitochondrial metabolism and neurodegeneration pathways - with possible implications for study design and intervention. Find it here: https://www.mdpi.com/1422-0067/23/23/14754
Congratulations Andrew, well done!
Some exciting news!
Andrew had been selected and recently attended the 4th ISN-JNC Flagship School: “Brain Metabolism in Health and Disease” in Schmerlenbach, Germany. This was a great event with the participation of speakers well known in the metabolism field!
Andrew is now in Madrid (Spain) for an internship funded by IBRO to run some experiments in the lab of Dr Angeles Arevalo at the Cajal Institute. Great results coming up...
Our lab has a new Postdoctoral fellow! Abdoh Taleb finished his doctoral studies in China and moved to Ireland to start his Postdoctoral position in Neuroscience funded by Science Foundation Ireland (SFI). Warm welcome from our team, Abdoh, and we do really hope you enjoy UL and Ireland!
Summer is here, this means new students are joining our lab to work on mitochondria-related projects. As a recipient of a Roibeárd Thornton Memorial- Janssen (companies of Johnson and Johnson) fellowship, Emma Noonan, now a 3rd year Bioscience student, will develop her skills in oxidative phosphorylation in cells under metabolic dysfunction.
Two ERASMUS students also join our team. Both from Spain, Rosa and Enrique will work on a project to investigate how tibolone regulates lipid metabolism in in vitro cells.
Welcome Emma, Rosa and Enrique. We hope you enjoy working with us over the summer.
Our PhD student Andrew has been awarded an Exchange fellowship from International Brain Research Organization (IBRO) for an internship in the laboratory of Dr Arevalo at Cajal Institute, Madrid, Spain. Part of his PhD project will be carried out there using the Four Core genotype mice to assess sex differences in mitochondria! Well done and congrats Andrew!
New original paper from our lab is out!!! We identify two novel ligands able to to bind CCR2, a membrane receptor widely involved in TBI-induced inflammation.
Our lab is delighted to have been awarded under the Frontiers for the Future Programme. Our grant will focus on neuroglobin, traumatic brain injury and tibolone and investigate how/why sex matters in mitochondria response to injury.
This is an international collaborative project with Dr David Ramírez (@davidmau @theramirezlab ) at Universidad de Concepción (Chile) to explore drugs that protect mitochondria in a sex-dependent manner following TBI.
We sincerely thank Science Foundation Ireland for this great support and for the evaluators/reviewers for taking the time and effort and for appreciating our proposal. New exciting research is coming up!!!
A new original paper from our group is out! This international collaborative paper with Janneth Gonzalez & team at PUJ (Colombia) and David Ramírez at Universidad de Concepción (Chile) reports prohibitin as a key mitochondrial protein being regulated by dihydrotestosterone (DHT), a metabolite of testosterone, and significantly involved in traumatic brain injury pathology. TBI patients suffer from hypogonadism, so treatment with DHT, a metabolite of testosterone, might be a promising therapeutic approach! #TBI #DHT #testosterone #prohibitin
Two new papers in collaboration with Janneth Gonzalez & team are now out!!! In the review by Vesga-Jiménez et al we deeply discussed the implications of fatty acids, in particular palmitic acid, an unsaturated lipid, in the pathological mechanisms underlying neurodegenerative diseases. In the second paper by Cabezas et al, we used machine learning and multivariate statistical analysis to integrate lipidomics and metabolomics of human astrocytes exposed to high concentration of palmitic acid and delved into how tibolone protects these cells under lipotoxicity.
Our lab is delighted to welcome Alannah Aherne, our new Research Assistant! She will be working on a project to explore protection by neuroglobin in traumatic brain injury. We are very excited to have you in our team!!! Welcome, Alannah!
Our lab participated in the 11th International Meeting on Steroids and Nervous System (virtual) from 19-22 February. Our PhD student Andrew McGovern made an outstanding oral presentation titled "Sex differences in mitochondrial metabolism from a proteomic analysis of a gonadectomised and tibolone treated mouse model". Well done Andrew!!!!
Event of this month: Our lab participated in the International School of Neuroscience held from December 13-17. This was a great and unforgettable experience with the participation of 20 students and live streaming from social media.
Congratulations to Andrew for winning the first PhD year presentation in the Research and Innovation day at Biological Sciences_UL . Well deserved and well done! More interesting things about sex differences to come!
We are hiring! Two SFI-funded positions are now available in our lab. We are looking for enthusiastic and research-driven candidates for a Postdoctoral fellow and Research Assistant positions interested in working on a project to better understand the hormonal regulation of mitochondria metabolism. Come work with us in a stunning, international, and multicultural University located in a wonderful area (Castletroy/Limerick) with lots to do! See our lab website (www.barretolab.org) for more info about us and our current projects. DM me if you have any question (George.Barreto@ul.ie)!
Applications due December 2nd.
Postdoctoral fellow (ID 047828)
Research Assistant (ID 047829)
New paper published in collaboration with Kristi A Kohlmeier and Altair Brito from University of Copenhagen (Denmark): https://pubmed.ncbi.nlm.nih.gov/34693879/
Bioscience Final Year Proyect season kicks off! Our lab welcomes Frances, Emer and Daniela, who will be working on mitochondria and neuroglobin-related projects!
Lea Lüdtke from RWTH Aachen University (Germany) is joining our group as Eramus Student - she will spend 3.5 months taking on a project to better understand the actions of hormones over brain cells. Welcome Lea!!!
Léana Aberrane, an Erasmus student from France, starts her internship in our group. Her project aims to better understand the role of neuroglobin and hormone signaling in the diseased brain! Welcome Léana!!!
We are delighted to have been funded an Ulysses 2020 award from Irish Research Council (IRC) and Health Research Board (HRB) to support our collaborative work with Dr Karim Belarbi from University of Lille (France). Our joint project aims to delve into the participation of mitochondrial proteins as potential biomarkers in Parkinson's disease patients.
Ally Crimmins joins our group as a Summer Bioscience student. Welcome Ally!
Our new logo has been launched! This identifies our key research areas and prospective studies!!!
Do you know some plants have estrogenic properties? Check out our new review on this interesting topic: Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause