June 2022

 

 

Summer is here, this means new students are joining our lab to work on mitochondria-related projects. As a recipient of a Roibeárd Thornton Memorial- Janssen (companies of Johnson and Johnson) fellowship, Emma Noonan, now a 3rd year Bioscience student, will develop her skills in oxidative phosphorylation in cells under metabolic dysfunction.  Welcome Emma! 

 

 

Our PhD student Andrew has been awarded an Exchange fellowship from International Brain Research Organization (IBRO) for an internship in the laboratory of Dr Arevalo at Cajal Institute, Madrid, Spain. Part of his PhD project will be carried out there using the Four Core genotype mice to assess sex differences in mitochondria! Well done and congrats Andrew!

 

May 2022

 

 

New original paper from our lab is out!!! We identify two novel ligands able to to bind CCR2, a membrane receptor widely involved in TBI-induced inflammation. 

Link: https://www.sciencedirect.com/science/article/pii/S0753332222005443 

Congratulations Kilian Sachdev and Kevin Lynch, both Bioscience graduates, for this outstanding work!!! 

Our lab is delighted to have been awarded under the Frontiers for the Future Programme. Our grant will focus on neuroglobin, traumatic brain injury and tibolone and investigate how/why sex matters in mitochondria response to injury.

This is an international collaborative project with Dr David Ramírez (@davidmau @theramirezlab ) at Universidad de Concepción (Chile) to explore drugs that protect mitochondria in a sex-dependent manner following TBI. 

We sincerely thank Science Foundation Ireland for this great support and for the evaluators/reviewers for taking the time and effort and for appreciating our proposal. New exciting research is coming up!!!

 

 

 

 

Our PhD student Andrew McGovern did a great presentation at Pint of Science Ireland in Limerick last night (12/05/2022). Congrats Andrew!!

March 2022

 

A new original paper from our group is out! This international collaborative paper with Janneth Gonzalez & team at PUJ (Colombia) and David Ramírez at Universidad de Concepción (Chile) reports prohibitin as a key mitochondrial protein being regulated by dihydrotestosterone (DHT), a metabolite of testosterone, and significantly involved in traumatic brain injury pathology. TBI patients suffer from hypogonadism, so treatment with DHT, a metabolite of testosterone, might be a promising therapeutic approach! #TBI #DHT #testosterone #prohibitin

Two new papers in collaboration with Janneth Gonzalez & team are now out!!! In the review by Vesga-Jiménez et al we deeply discussed the implications of fatty acids, in particular palmitic acid, an unsaturated lipid, in the pathological mechanisms underlying neurodegenerative diseases. In the second paper by Cabezas et al, we used machine learning and multivariate statistical analysis to integrate lipidomics and metabolomics of human astrocytes exposed to high concentration of palmitic acid and delved into how tibolone protects these cells under lipotoxicity. 

Our lab is delighted to welcome Alannah Aherne, our new Research Assistant! She will be working on a project to explore protection by neuroglobin in traumatic brain injury. We are very excited to have you in our team!!! Welcome, Alannah! 

February 2022

 

Our lab participated in the 11th International Meeting on Steroids and Nervous System (virtual) from 19-22 February. Our PhD student Andrew McGovern made an outstanding oral presentation titled "Sex differences in mitochondrial metabolism from a proteomic analysis of a gonadectomised and tibolone treated mouse model". Well done Andrew!!!!


December 2021

 

Event of this month: Our lab participated in the International School of Neuroscience held from December 13-17.  This was a great and unforgettable experience with the participation of 20 students and live streaming from social media. 

 

November 2021

 

Congratulations to Andrew for winning the first PhD year presentation in the Research and Innovation day at Biological Sciences_UL . Well deserved and well done! More interesting things about sex differences to come!

We are hiring! Two SFI-funded positions are now available in our lab. We are looking for enthusiastic and research-driven candidates for a Postdoctoral fellow and Research Assistant positions interested in working on a project to better understand the hormonal regulation of mitochondria metabolism. Come work with us in a stunning, international, and multicultural University located in a wonderful area (Castletroy/Limerick) with lots to do! See our lab website (www.barretolab.org) for more info about us and our current projects. DM me if you have any question (George.Barreto@ul.ie)!

Applications due December 2nd.

Apply here:
https://lnkd.in/e6yS7Fze

Postdoctoral fellow (ID 047828)

Research Assistant (ID 047829)

Abstracts submission is open! Check out our event's page: https://sites.google.com/view/neurosteroids2022

New paper published in collaboration with Kristi A Kohlmeier and Altair Brito from University of Copenhagen (Denmark): https://pubmed.ncbi.nlm.nih.gov/34693879/

September 2021

 

Bioscience Final Year Proyect season kicks off! Our lab welcomes Frances, Emer and Daniela, who will be working on mitochondria and neuroglobin-related projects!

Lea Lüdtke from RWTH Aachen University (Germany) is joining our group as Eramus Student - she will spend 3.5 months taking on a project to better understand the actions of hormones over brain cells. Welcome Lea!!!

August 2021

 

 

Our new review has just been published! Get to know more about how estrogenic compounds regulate neuroglobin signaling.

Link: https://www.mdpi.com/2073-4409/10/8/1907  

 

Interested to know how machine learning as a high-throughput approach is used to predict disease onset and development? Check out our new review paper! 

 

Link: https://www.mdpi.com/2218-273X/11/8/1132 

July 2021

 

Léana Aberrane, an Erasmus student from France, starts her internship in our group. Her project aims to better understand the role of neuroglobin and hormone signaling in the diseased brain! Welcome Léana!!!

June 2021

We are delighted to have been funded an Ulysses 2020 award from Irish Research Council (IRC) and Health Research Board (HRB) to support our collaborative work with Dr Karim Belarbi from University of Lille (France). Our joint project aims to delve into the participation of mitochondrial proteins as potential biomarkers in Parkinson's disease patients. 

Ally Crimmins joins our group as a Summer Bioscience student. Welcome Ally! 

 

 

Our new logo has been launched! This identifies our key research areas and prospective studies!!!

 

 

Do you know some plants have estrogenic properties? Check out our new review on this interesting topic: Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause