🧠⏰ Our new study shows that obesity disrupts the body’s clock, and the broken clock worsens metabolism.
Using mouse transcriptional data (normal vs. high-fat diet), we combined biological enrichment with Boolean network modeling to map gene-gene interactions centred on lipid metabolism.
We found under-expression of core clock genes (Bmal1, Clock) and a reciprocal loop: lipid metabolic disruption ↔ circadian misalignment amplify each other, undermining brain homeostasis.
These insights point to circadian pathways as therapeutic targets in obesity-related metabolic disorders.
Key takeaways:
🔬 Transcriptomics + systems modeling reveal a clock-lipid axis
🧩 Core clock genes downregulated in obesity (Bmal1, Clock)
🔁 Bidirectional disruption suggests circadian-targeted interventions
Want to know more? Please see here: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0331218
