Featured Publications

 

- McGovern AJ, González J, Ramírez D, Barreto GE. Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology. Int Immunopharmacol. 2022. doi: 10.1016/j.intimp.2022.108721

 

- Vesga-Jimenez DJ, Martin-Jimenez CA, Grismaldo Rodriguez A, Aristizabal-Pachon AF, Pinzon A, Barreto GE, Ramirez D, Gonzalez J. Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis. Int J Mol Sci. 2022 23 (12). doi: 10.3390/ijms23126454

 

- McGovern AJ and Barreto GE. Mitochondria Dysfunction and Inflammation in Traumatic Brain Injury: Androgens to the Battlefront. Androgens: Clinical Research and Therapeutics. 2021 Dec 23;2(1):304-315. doi: 10.1089/andro.2021.0017.

 

- Barreto GE, McGovern AJ, Garcia-Segura LM. Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds. Cells. 2021 Jul 27;10(8):1907. doi: 10.3390/cells10081907.

 

- McGovern AJ, Barreto GE. Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury. Biomed Pharmacother. 2021 Aug;140:111769. doi: 10.1016/j.biopha.2021.111769.

 

- Martin-Jiménez C, González J, Vesga D, Aristizabal A, Barreto GE. Tibolone Ameliorates the Lipotoxic Effect of Palmitic Acid in Normal Human Astrocytes. Neurotox Res. 2020 Oct;38(3):585-595. doi: 10.1007/s12640-020-00247-4.

 

- Del Río JP, Molina S, Hidalgo-Lanussa O, Garcia-Segura LM, Barreto GE. Tibolone as Hormonal Therapy and Neuroprotective Agent. Trends Endocrinol Metab. 2020 Oct;31(10):742-759. doi: 10.1016/j.tem.2020.04.007.

 

- Osorio D, Pinzón A, Martín-Jiménez C, Barreto GE, González J. Multiple Pathways Involved in Palmitic Acid-Induced Toxicity: A System Biology Approach. Front Neurosci. 2020 Jan 31;13:1410. doi: 10.3389/fnins.2019.01410.

 

- Hidalgo-Lanussa O, Baez-Jurado E, Echeverria V, Ashraf GM, Sahebkar A, Garcia-Segura LM, Melcangi RC, Barreto GE. Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds. J Neuroendocrinol. 2020 Jan;32(1):e12776. doi: 10.1111/jne.12776.

 

- González-Giraldo Y, Garzón-Benitez AV, Forero DA, Barreto GE. TERT inhibition leads to reduction of IL-6 expression induced by palmitic acid and interferes with the protective effects of tibolone in an astrocytic cell model. J Neuroendocrinol. 2019 Aug;31(8):e12768. doi: 10.1111/jne.12768.

 

- González-Giraldo Y, Forero DA, Echeverria V, Garcia-Segura LM, Barreto GE. Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta. Mol Cell Endocrinol. 2019 Apr 15;486:65-78. doi: 10.1016/j.mce.2019.02.017.

 

- Martin-Jiménez C, Gaitán-Vaca DM, Areiza N, Echeverria V, Ashraf GM, González J, Sahebkar A, Garcia-Segura LM, Barreto GE. Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury. Neuroendocrinology. 2019;108(2):142-160. doi: 10.1159/000495078.

 

- Baez-Jurado E, Guio-Vega G, Hidalgo-Lanussa O, González J, Echeverria V, Ashraf GM, Sahebkar A, Barreto GE. Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury. Mol Neurobiol. 2019 Jul;56(7):5167-5187. doi: 10.1007/s12035-018-1442-9.

 

- Martin-Jiménez C, Gaitán-Vaca DM, Areiza N, Echeverria V, Ashraf GM, González J, Sahebkar A, Garcia-Segura LM, Barreto GE. Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury. Neuroendocrinology. 2019;108(2):142-160. doi: 10.1159/000495078.

 

- Crespo-Castrillo A, Yanguas-Casás N, Arevalo MA, Azcoitia I, Barreto GE*, Garcia-Segura LM*. The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury. Mol Neurobiol. 2018 Nov;55(11):8651-8667. doi: 10.1007/s12035-018-1008-x.

 

- Baez-Jurado E, Hidalgo-Lanussa O, Guio-Vega G, Ashraf GM, Echeverria V, Aliev G, Barreto GE. Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro. Mol Neurobiol. 2018 Jun;55(6):5377-5392. doi: 10.1007/s12035-017-0771-4.

 

- Baez-Jurado E, Vega GG, Aliev G, Tarasov VV, Esquinas P, Echeverria V, Barreto GE. Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay. Mol Neurobiol. 2018 Mar;55(3):2285-2300. doi: 10.1007/s12035-017-0481-y.

 

- Hidalgo-Lanussa O, Ávila-Rodriguez M, Baez-Jurado E, Zamudio J, Echeverria V, Garcia-Segura LM, Barreto GE. Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta. Mol Neurobiol. 2018 Jul;55(7):5462-5477. doi: 10.1007/s12035-017-0777-y.

 

- González-Giraldo Y, Garcia-Segura LM, Echeverria V, Barreto GE. Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid. Mol Neurobiol. 2018 May;55(5):4453-4462. doi: 10.1007/s12035-017-0667-3.

 

- Acaz-Fonseca E, Avila-Rodriguez M, Garcia-Segura LM, Barreto GE. Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions. Prog Neurobiol. 2016 Sep;144:5-26. doi: 10.1016/j.pneurobio.2016.06.002.

 

- Avila-Rodriguez M, Garcia-Segura LM, Hidalgo-Lanussa O, Baez E, Gonzalez J, Barreto GE. Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression. Mol Cell Endocrinol. 2016 Sep 15;433:35-46. doi: 10.1016/j.mce.2016.05.024.

 

- Ávila Rodriguez M, Garcia-Segura LM, Cabezas R, Torrente D, Capani F, Gonzalez J, Barreto GE. Tibolone protects T98G cells from glucose deprivation. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:294-303. doi: 10.1016/j.jsbmb.2014.07.009.

 

 

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