3- Dysregulation of lipid metabolism and neuroimmune response following brain damage.
Traumatic brain injury (TBI) causes profound dysregulation of lipid metabolism in the brain. The mechanical damage itself provokes membrane disruption, leading to an aberrant release of lipids and cholesterol from this subcellular compartment. More importantly, mitochondrial dysfunction is a hallmark of TBI pathology, affecting the way cells metabolize lipids in this organelle. We are keen on thoroughly understanding how this leads to chronic inflammation and a strong neuroimmune response.
Accumulation of lipids in the brain is a chronic feature in TBI and to better understand how this affects cell fate we use in silico and in vitro approaches to simulate this pathological alteration.