3- Dysregulation of lipid metabolism and neuroimmune response following brain damage.
Traumatic brain injury (TBI) leads to a profound dysregulation of lipid metabolism in the brain, the mechanical damage per se provokes membrane disruption which leads to an aberrant release of lipids and cholesterol from this subcellular compartment. More importantly, mitochondria dysfunction is a hallmark of TBI pathology affecting the way cells metabolise lipids in this organelle. We are keen to thoroughly understand how this leads to chronic inflammation and strong neuroimmune response.
Accumulation of lipids in the brain is a chronic feature in TBI and to better understand how this affects cell fate we use in silico and in vitro approaches to simulate this pathological alteration.